The blocking of the PDE5 can spill onto other body parts causing vasodilatation and increased pressure. If you have kidney disease, liver or heart related illnesses he may just say no.
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Confused? Make a cycle. Guanylate cyclase turns GTP into cGMP causing smooth muscles to settle back. PDE turns cGMP into GTP resulting in the smooth muscles to go back to their constricted maintain. Nitric oxide turns this cycle on from a nerve impulse generated your past brain.
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